From basic understanding of cell networks to their modulation and engineering for health and industrial applications
In recent years it has emerged with increasing clarity that enzymes and proteins do not work alone within the cell but are organized in complex and interconnected networks, which also include other classes of (macro)molecules, such as nucleic acids and small molecules and metabolites. Although these networks sometimes coincide with those presented in biochemistry textbooks, their complexity and interconnectivity are often more significant. Consequently, our approach to understanding cellular functions, as well as our approaches to modifying individual proteins or pathways, must necessarily take this complexity into account. The development of computational and experimental tools and methodologies puts us today in a position to face this complexity with approaches and perspectives that were unimaginable just a few years ago. Many tools make it possible to predict and study structural properties of proteins along with their interactions. Omic technologies are moving towards an ever-increasing ability to tackle intercellular and spatial variability. Computational approaches to the properties of biochemical networks and their simulation allow rigorous and systematic testing of the effects of the modifications of the network's wiring or alterations of the biochemical properties of its single components. In the biotechnological field, this approach makes it possible to modify pre-existing pathways or design de novo pathways to produce molecules with high added value. In health, these new methodologies pave the way to a genuinely personalized therapeutic approach of particular value for multifactorial diseases such as tumors and neurodegenerative disorders. This meeting brings together three of the scientific groups in which the Italian Society of Biochemistry and Molecular Biology is organized and whose topics fit into this new molecular approach to life sciences and their applications. We wish to invite colleagues, research fellows, post-docs and PhD students working or interested in the field to contribute and participate to the conference hoping that there will be the chance for scientific discussion to improve "our own network" as scientists involved in these topics expanding the SIB group community.
The Scientific Committee
Chiara Schiraldi & Mariarita Brancaccio - Biotechnology
Marco Vanoni & Giulia Babbi - Computational and Systems Biochemistry
Gabriella Tedeschi & Riccardo Miggiano - Proteins
Attention:
Registration is open deadline 8th May 2023
Abstract submission is open deadline 2nd May 2023
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